Publications

Latest publications 2024

A Glycolipid-Peptide-Hapten Tricomponent Conjugate Vaccine Generates Durable Antihapten Antibody Responses in Mice

T. E. Pankhurst, I. Montgomerie, A. Marshall, S. L. Draper, T. Bilbrough, K. R. Button, et al.

ACS Chemical Biology 2024 Vol. 19 Issue 6 Pages 1366-1375

Two Iron(II), α-Ketoglutarate-Dependent Enzymes Encoded by the PPZ Gene Cluster of Metarhizium majus Enable Production of 8-Hydroxyperamine

K. W. Rothchild, M. Hagar, D. Berry and K. S. Ryan

Journal of the American Chemical Society 2024

The Synthesis and Reactivity of Naphthoquinonynes

R. de Carvalho, J. Wood, R. Almeida, N. Berry, E. da Silva Júnior, J. Bower

Angewandte Chemie International Edition 2024 Vol. n/a Issue n/a Pages e202400188

Synthesis and Reactivity of Discrete Europium(II) Hydride Complexes

G. M. Richardson, M. J. Evans, T. Rajeshkumar, J. A. J. McCone, S. A. Cameron, L. Maron, et al.

Chemistry—A European Journal 2024 Vol. n/a Issue n/a Pages e202400681

Synthesis and Detection of BODIPY-, Biotin-, and 19F- Labeled Single-Entity Dendritic Heparan Sulfate Mimetics

S. Spijkers-Shaw, R. Devlin, N. J. Shields, X. Feng, T. Peck, G. Lenihan-Geels, et al.

Angewandte Chemie International Edition 2024 Vol. n/a Issue n/a Pages e202316791

Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets

I. A. Guan, J. S. T. Liu, R. C. Sawyer, X. Li, W. Jiao, Y. Jiramongkol, et al.

ACS Central Science 2024 Vol. 10 Issue 2 Pages 344-357

Ulvans are Not Equal-Linkage and Substitution Patterns in Ulvan Polysaccharides Differ with Ulva Morphology

J. Kidgell, C. R. Glasson, M. Magnusson, I. M. Sims, S. F. Hinkley, R. de Nys, et al.

Carbohydrate Polymers 2024 Pages 121962

Preclinical evaluation of therapeutic vaccines for chronic hepatitis B that stimulate antiviral activities of T cells and NKT cells

A. H. Mooney, S. L. Draper, O. K. Burn, R. J. Anderson, B. J. Compton, C. Tang, et al.

JHEP Reports 2024 Pages 101038

Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality

A. S. Paparella, I. Brew, H. A. Hong, W. Ferriera, S. Cutting, F. Lamiable-Oulaidi, et al.

ACS Infectious Diseases 2024

Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes.

M. Gamez, H. E. Elhegni, S. Fawaz, K. H. Ho, N. W. Campbell, D. A. Copland, et al.

Cardiovascular Diabetology 2024 Vol. 23 Issue 1 Pages 50

Versatility of a diamidosilylether ligand supporting yttrium complexes: Synthesis, structure and reactivity

M. D. Anker, M. J. Evans, S. A. Cameron and G. Laufersky

Polyhedron 2024 Vol. 247 Pages 116741

Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients

S. Sala, P. Nitschke, R. Masuda, N. Gray, N. G. Lawler, J. M. Wood, et al.

Journal of Proteome Research 2024

NKT agonist-antigen conjugates as cancer vaccines

B. J. Compton and G. F. Painter

Critical Reviews™ in Oncogenesis 2024 Vol. 29

Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition

G. T. Bedard, N. Gilaj, K. Peregrina, I. Brew, E. Tosti, K. Shaffer, et al.

Journal of Biological Chemistry 2024 Vol. 300 Issue 1

2023

Chemoenzymatic Synthesis of 3′-Deoxy-3′, 4′-didehydro-cytidine triphosphate (ddhCTP)

J. H. Lee, J. M. Wood, S. C. Almo, G. B. Evans, L. D. Harris and T. L. Grove

ACS bio & med Chem Au 2023 Vol. 3 Issue 4 Pages 322-326

The novel HS-mimetic, Tet-29, regulates immune cell trafficking across barriers of the CNS during inflammation

T. Peck, C. Davis, G. Lenihan-Geels, M. Griffiths, S. Spijkers-Shaw, O. V. Zubkova, et al.

Journal of Neuroinflammation 2023 Vol. 20 Issue 1 Pages 251

Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition

G. T. Bedard, N. Gilaj, K. Peregrina, I. Brew, E. Tosti, K. Shaffer, et al.

Journal of Biological Chemistry 2024 Vol. 300 Issue 1 Pages 105492

Synthetic 5-amino-6-D-ribitylaminouracil paired with inflammatory stimuli facilitates MAIT cell expansion in vivo

A. G. Nelson, H. Wang, P. M. Dewar, E. M. Eddy, S. Li, X. Y. Lim, et al.

Frontiers in Immunology 2023 Vol. 14

mRNA Synthesis and Encapsulation in Ionizable Lipid Nanoparticles

R. E. McKenzie, J. J. Minnell, M. Ganley, G. F. Painter and S. L. Draper

Current Protocols 2023 Vol. 3 Issue 9 Pages e898

In Vitro Effects of Aminopyridyl Ligands Complexed to Copper (II) on the Physiology and Interaction Process of Trypanosoma cruzi

R. Silva-Oliveira, L. S. Sangenito, A. Reddy, T. Velasco-Torrijos, A. L. Santos and M. H. Branquinha

Tropical Medicine and Infectious Disease 2023 Vol. 8 Issue 5 Pages 288

Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic

R. A. Smith, X. Luo, X. Lu, T. C. Tan, B. Q. Le, O. V. Zubkova, et al.

Biomaterials Advances 2023 Vol. 155 Pages 213671

Engineering Broad-spectrum Inhibitors of Inflammatory Chemokines from a New Family of Tick Evasins

S. Devkota, P. Aryal, W. Jiao, A. Perry, S. Panjikar, R. Payne, et al.

Nature Communications 2023 Vol. 14 Issue 1 Pages 4204

A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening

M. H. Rich, A. V. Sharrock, T. S. Mulligan, F. Matthews, A. S. Brown, H. R. Lee-Harwood, et al.

Cell Chemical Biology 2023 Vol. 30 Issue 12 Pages 1680-1691. e6

Allosteric inhibition of Staphylococcus aureus MenD by 1, 4-dihydroxy naphthoic acid: a feedback inhibition mechanism of the menaquinone biosynthesis pathway

T. Stanborough, N. A. T. Ho, E. M. Bulloch, G. Bashiri, S. S. Dawes, E. W. Akazong, et al.

Philosophical Transactions of the Royal Society B 2023 Vol. 378 Issue 1871 Pages 20220035

A Resistant Mutant of Plasmodium falciparum Purine Nucleoside Phosphorylase uses Wild-type Neighbors to Maintain Parasite Survival

Y. V. T. Minnow, R. K. Harijan and V. L. Schramm

Journal of Biological Chemistry 2021 Vol. 296 Pages 100342

Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides

S. R. Messenger, E. M. McGuinniety, L. J. Stevenson, J. G. Owen, G. L. Challis, D. F. Ackerley, et al.

Nature Chemical Biology 2023 Pages 1-10

Functional Crosstalk between Discrete Indole Terpenoid Gene Clusters in Tolypocladium album

T. R. Hibbard, R. M. McLellan, L. J. Stevenson, A. T. Richardson, M. J. Nicholson and E. J. Parker

Organic Letters 2023 Vol. 25 Issue 41 Pages 7470-7475

Expedient synthesis of imino-C-nucleoside fleximers featuring a one-pot procedure to prepare aryl triazoles

Wong CHA, Hubert JG, Sparrow KJ, Harris LD, Tyler PC, Brimble MA

Organic & Biomolecular Chemistry 2023

mRNA vaccine against malaria tailored for liver-resident memory T cells

Ganley M, Holz LE, Minnell JJ, de Menezes MN, Burn OK, Poa KCY, Draper SL, English K, Chan STS, Anderson RJ, Compton BJ, Marshall AJ, Cozijnsen A, Chua YC, Ge Z, Farrand KJ, Mamum JC, Xu C, Cockburn IA, Yui K, Bertolino P, Gras S, Le Nours J, Rossjohn J, Fernandez-Ruiz D, McFadden GI, Ackerley DF, Painter GF, Hermans IF, Heath WR

Nat Immunol (2023)

MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity

Pankhurst TE, Buick KH, Lange JL, Marshall AJ, Button KR, Palmer OR, Farrand KJ, Montgomerie I, Bird TW, Mason NC

Cell Reports 2023

Synthesis of a putative ddhCTP metabolite ddhC-homocysteine

Wood JM, Buckler JN, Almo SC, Evans GB, Grove TL, Harris LD

Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry, (2023)

The discovery of 12β-methyl-17-epi-18-nor-bile acids as potent and selective TGR5 agonists

Luxenburger A, Harris LD, Ure EM, Jiao W, Woolhouse AD, Cameron SA, Weymouth-Wilson A, Furneaux RH, Pitman JL, Hinkley SFR

European Journal of Medicinal Chemistry (2023)

Syntheses and crystal structure of a (2,6-diisopropyldinaphtho[2,1-d:1′,2′-f][1,3]dithiepin-4-yl)(phenyl)methanol atropisomer

Beare N, Painter GF, McAdam CJ

Acta Crystallographica Section E: Crystallographic Communications (2023), pp. 241-245

Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: a feedback inhibition mechanism of the menaquinone biosynthesis pathway

Stanborough T, Ho NAT, Bulloch EMM, Bashiri G, Dawes SS, Akazong EW, Titterington J, Allison TM, Jiao W, Johnston JM

Philosophical Transactions of the Royal Society B: Biological Sciences (2023)

Structure, mechanism and inhibition of anthranilate phosphoribosyltransferase

Scully TW, Jiao W, Mittelstädt G, Parker EJ

Philosophical Transactions of the Royal Society B: Biological Sciences (2023)

Generation of Alternate Indole Diterpene Architectures in Two Species of Aspergilli

Bundela R, Cameron RC, Singh AJ, McLellan RM, Richardson AT, Berry D, Nicholson MJ, Parker EJ

Journal of the American Chemical Society (2023), pp. 2754-2758

Development of a compartmentalised self-replication protocol for selection of superior blunt-end DNA ligases

Stevenson LJ, Robins KJ, Sharma JK, Williams EM, Sharrock AV, Williamson AK, Arcus VL, Patrick WM, Ackerley DF

Enzyme and Microbial Technology 2023 Vol. 163 Pages 110153

Benchtop nuclear magnetic resonance spectroscopy in forensic chemistry

Draper SL, McCarney ER

Philosophical Transactions of the Royal Society B: Biological Sciences (2023)

Conformational interdomain flexibility in a bacterial α-isopropylmalate synthase is necessary for leucine biosynthesis

Bai Y, Jiao W, Vörster J, Parker EJ

Journal of Biological Chemistry (2023)

Chemical modulation of microtubule structure through the laulimalide/peloruside site

Estévez-Gallego J, Álvarez-Bernad B, Pera B, Wullschleger C, Raes O, Menche D, Martínez JC, Lucena-Agell D, Prota AE, Bonato F

Structure (2023), pp. 88-99.e5

An Isomer of Galidesivir That Potently Inhibits Influenza Viruses and Members of the Bunyavirales Order

Sparrow KJ, Shrestha R, Wood JM, Clinch K, Hurst BL, Wang H, Gowen BB, Julander JG, Tarbet EB, McSweeney AM

ACS Medicinal Chemistry Letters (2023)

Green Synthesis of Carbon Nanoparticles (CNPs) from Biomass for Biomedical Applications

Qasim M, Clarkson AN, Hinkley SFR

International Journal of Molecular Sciences (2023)

3α,7-Dihydroxy-14(13→12)abeo-5β,12α(H),13β(H)-cholan-24-oic Acids Display Neuroprotective Properties in Common Forms of Parkinson’s Disease

Luxenburger A, Clemmens H, Hastings C, Harris LD, Ure EM, Cameron SA, Aasly J, Bandmann O, Weymouth-Wilson A, Furneaux RH

Biomolecules (2023)

A randomised controlled trial of long NY-ESO-1 peptide-pulsed autologous dendritic cells with or without alpha-galactosylceramide in high-risk melanoma

Dasyam N, Sharples KJ, Barrow C, Huang Y, Bauer E, Mester B, Wood CE, Authier-Hall A, Dzhelali M, Ostapowicz T

Cancer Immunology Immunotherapy (2023)

Synthesis and Biological Evaluation of Peptide-Adjuvant Conjugate Vaccines with Increasing Antigen Content

Cooney TR, Farrand K, Draper SL, Anderson RJ, Rendle PM, Hermans IF, Compton BJ, Painter GF

Bioconjugate Chemistry (2023)

Novel 4-O-β-d-xylopyranosyl-3,6-anhydro-l-galactopyranosyl disaccharide units in a polysaccharide from the red alga Pyrophyllon subtumens

Falshaw R, Furneaux RH, Sims IM, Hinkley SFR, Kidgell JT, Bell TJ

Carbohydrate Polymers (2023)

Shear and temperature sensitivity of a shear-thickening biopolymer from the New Zealand black tree fern

Bisht A, Goh KKT, Sims IM, Edwards PJB, Matia-Merino L

Food Hydrocolloids (2023)

Genomic insights from Monoglobus pectinilyticus: a pectin-degrading specialist bacterium in the human colon

Kim, C. C., G. R. Lunken, W. J. Kelly, M. L. Patchett, Z. Jordens, G. W. Tannock, I. M. Sims, T. J. Bell, D. Hedderley, B. Henrissat and D. I. Rosendale

The ISME Journal (2023)

Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.

Glockzin K, Meneely KM, Hughes R, Maatouk SW, Piña GE, Suthagar K, Clinch K, Buckler JN, Lamb AL, Tyler PC, Meek TD, Katzfuss A.

Biochemistry. 2023;62(14):2182-201.

Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins

Devkota SR, Aryal P, Pokhrel R, Jiao W, Perry A, Panjikar S, Payne RJ, Wilce MCJ, Bhusal RP, Stone MJ

Nature Communications 2023 Vol. 14 Issue 1 Pages 4204

Novel 4-O-β-d-xylopyranosyl-3,6-anhydro-l-galactopyranosyl disaccharide units in a polysaccharide from the red alga Pyrophyllon subtumens

Falshaw R, Furneaux RH, Sims IM, Hinkley SFR, Kidgell JT, Bell TJ

Carbohydrate Polymers 2023 Vol. 318 Pages 121066

Residence Times for Femtomolar and Picomolar Inhibitors of MTANs

Brown M, Tyler PC, Schramm VL

Biochemistry 2023 Vol. 62 Issue 11 Pages 1776-1785

Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins

Devkota SR, Aryal P, Pokhrel R, Jiao W, Perry A, Panjikar S, Payne RJ, Wilce MCJ, Bhusal RP, Stone MJ

Nature Communications 2023 Vol. 14 Issue 1 Pages 4204

Galidesivir Triphosphate Promotes Stalling of Dengue-2 Virus Polymerase Immediately Prior to Incorporation

Deshpande S, Huo W, Shrestha R, Sparrow K, Wood JM, Evans GB, Harris LD, Kingston RL, Bulloch EMM

ACS Infectious Diseases 2023

Chemoenzymatic Synthesis of 3′-Deoxy-3′,4′-didehydro-cytidine triphosphate (ddhCTP)

Lee JH, Wood JM, Almo SC, Evans GB, Harris LD

ACS Bio & Med Chem Au 2023

Phosphoinositide and redox dysregulation by the anticancer methylthioadenosine phosphorylase transition state inhibitor

Salita T, Rustam YH, Hofferek V, Jackson M, Tollestrup I, Sheridan JP, Schramm VL, Evans GB, Reid GE, Munkacsi AB

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2023 Vol. 1868 Issue 9 Pages 159346

2022

Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase

Minnow YVT, Suthagar K, Clinch K, Ducati RG, Ghosh A, Buckler JN, Harijan RK, Cahill SM, Tyler PC, Schramm VL

ACS Chemical Biology (2022), pp. 3407-3419

Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition

Potts KS, Cameron RC, Metidji A, Ghazale N, Wallace LS, Leal-Cervantes AI, Palumbo R, Barajas JM, Gupta V, Aluri S

Cell Reports (2022)

Biosynthesis of Nodulisporic Acids: A Multifunctional Monooxygenase Delivers a Complex and Highly Branched Array

Richardson AT, Cameron RC, Stevenson LJ, Singh AJ, Lukito Y, Berry D, Nicholson MJ, Parker EJ

Angewandte Chemie International Edition (2022)

A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells

Lim HJ, Wubben JM, Garcia CP, Cruz-Gomez S, Deng J, Mak JYW, Hachani A, Anderson RJ, Painter GF, Goyette J

The Journal of Cell Biology (2022)

The Venturia inaequalis effector repertoire is dominated by expanded families with predicted structural similarity, but unrelated sequence, to avirulence proteins from other plant-pathogenic fungi

Rocafort M, Bowen JK, Hassing B, Cox MP, McGreal B, de la Rosa S, Plummer KM, Bradshaw RE, Mesarich CH

The Journal of Cell Biology (2022)

Free charge photogeneration in a single component high photovoltaic efficiency organic semiconductor

Price MB, Hume PA, Ilina A, Wagner I, Tamming RR, Thorn KE, Jiao W, Goldingay A, Conaghan PJ, Lakhwani G

Nature Communications (2022)

The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues

Gai S, Suthagar K, Shaffer KJ, Jiao W, Minnow YVT, Glockzin K, Maatouk SW, Katzfuss A, Meek TD, Schramm VL

Bioorganic and Medicinal Chemistry (2022)

Effect of carrier molecular weight on physicochemical properties and the in vitro immune-stimulatory activity of the CpG-dextran conjugates

Nguyen HV, Campbell K, Painter GF, Young SL, Walker GF

International Journal of Pharmaceutics (2022)

Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine-Guanine Phosphoribosyltransferases

Glockzin K, Kostomiris D, Minnow YVT, Suthagar K, Clinch K, Gai S, Buckler JN, Schramm VL, Tyler PC, Meek TD

Biochemistry (2022), pp. 2088-2105

Precise Positioning of Water Is Critical for Hydrolysis Catalyzed by 5′-Methylthioadenosine Nucleosidase

Jiao W, Mittelstädt G, Parker EJ

Biochemistry (2022), pp. 1883-1893

Using Full-Spectrum Flow Cytometry to Phenotype Memory T and NKT Cell Subsets with Optimized Tissue-Specific Preparation Protocols

Farrand K, Holz LE, Ferrer-Font L, Wilson MD, Ganley M, Minnell JJ, Tang CW, Painter GF, Heath WR, Hermans IF

Current Protocols (2022)

Synthesis of Novel Glycolipid Mimetics of Heparan Sulfate and Their Application in Colorectal Cancer Treatment in a Mouse Model

Spijkers-Shaw S, Campbell K, Shields NJ, Miller JH, Rendle PM, Jiao W, Young SL, Zubkova OV

Chemistry: An Asian Journal (2022)

Unraveling the binding mode of a methamphetamine aptamer: A spectroscopic and calorimetric study

Sester C, McCone JAJ, Sen A, Vorster J, Harvey JE, Hodgkiss JM

Biophysical Journal (2022), pp. 2193-2205

Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication

Hsu JCC, Laurent-Rolle M, Pawlak JB, Xia H, Kunte A, Hee JS, Lim J, Harris LD, Wood JM, Evans GB

Molecular Cell (2022), pp. 1631-1642.e6

C5-Iminosugar modification of casein kinase 1δ lead 3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)isoxazole promotes enhanced inhibitor affinity and selectivity

von Drathen T, Ure EM, Kirschner S, Roth A, Meier L, Woolhouse AD, Cameron SA, Knippschild U, Peifer C, Luxenburger A

Archiv der Pharmazie (2022)

Recovery of Post-Stroke Spatial Memory and Thalamocortical Connectivity Following Novel Glycomimetic and rhBDNF Treatment

Houlton J, Zubkova OV, Clarkson AN

International Journal of Molecular Sciences (2022)

Variability in the composition of porcine mucosal heparan sulfates

Sargison L, Smith RAA, Carnachan SM, Daines AM, Brackovic A, Kidgell JT, Nurcombe V, Cool SM, Sims IM, Hinkley SFR

Carbohydrate Polymers (2022)

Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1

Lamiable-Oulaidi F, Harijan RK, Shaffer KJ, Crump DR, Sun Y, Du Q, Gulab SA, Khan AA, Luxenburger A, Woolhouse AD

Journal of Medicinal Chemistry (2022), pp. 5462-5494

Aminoacylation of Indole Diterpenes by Cluster-Specific Monomodular NRPS-like Enzymes

McLellan RM, Cameron RC, Nicholson MJ, Parker EJ

Organic Letters (2022), pp. 2332-2337

Synthesis of Novel C/D Ring Modified Bile Acids

Landaeta Aponte RA, Luxenburger A, Cameron SA, Weymouth-Wilson A, Furneaux RH, Harris LD, Compton BJ

Molecules (2022)

Localisation of phosphoinositides in the grass endophyte Epichloë festucae and genetic and functional analysis of key components of their biosynthetic pathway in E. festucae symbiosis and Fusarium oxysporum pathogenesis

Hassing B, Candy A, Eaton CJ, Fernandes TR, Mesarich CH, Di Pietro A, Scott B

Fungal Genetics and Biology (2022), pp. 103669-103669

Synthesis of 12β-methyl-18-nor-avicholic acid analogues as potential TGR5 agonists

Ure EM, Harris LD, Cameron SA, Weymouth-Wilson A, Furneaux RH, Pitman JL, Hinkley SF, Luxenburger A

Organic and Biomolecular Chemistry (2022), pp. 3511-3527

Uncoupling Molecular Testing for SARS-CoV-2 From International Supply Chains

Stanton JAL, O'Brien R, Hall RJ, Chernyavtseva A, Ha HJ, Jelley L, Mace PD, Klenov A, Treece JM, Fraser JD

Frontiers in Public Health (2022)

Preparation of Soil Metagenome Libraries and Screening for Gene-Specific Amplicons

Stevenson LJ, Ackerley DF, Owen JG

Methods in Molecular Biology (2022), pp. 3-17

Reactivity of a β-diketiminate ytterbium(II) hydride with cyclopentadiene derivatives

Richardson GM, Howarth J, Evans MJ, Edwards AJ, Cameron SA, Anker MD

Journal of Coordination Chemistry (2022), pp. 1954-1966

Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect

Prasit KK, Ferrer-Font L, Burn OK, Anderson RJ, Compton BJ, Schmidt AJ, Mayer JU, Chen CJJ, Dasyam N, Ritchie DS

OncoImmunology (2022)

Nuisance mucilage produced by Lindavia intermedia (Bacillariophyceae) in New Zealand lakes

Novis PM, Bell TJ, Fraser P, Luiten CA, Hinkley SFR, Borges H, Schallenberg M

Inland Waters (2022), pp. 232-244

Structural characterization of ulvans extracted from blade (Ulva ohnoi) and filamentous (Ulva tepida and Ulva prolifera) species of cultivated Ulva

Glasson CRK, Luiten CA, Carnachan SM, Daines AM, Kidgell JT, Hinkley SFR, Praeger C, Andrade Martinez M, Sargison L, Magnusson M

International Journal of Biological Macromolecules (2022), pp. 571-579

Glycolipid-peptide conjugate vaccines elicit CD8+ T-cell responses and prevent breast cancer metastasis,

Burn OK, Farrand K, Pritchard T, Draper S, Tang CW, Mooney AH, Schmidt AJ, Yang SH, Williams GM, Brimble MA

Clinical and Translational Immunology (2022)

6″-Modifed α-GalCer-peptide conjugate vaccine candidates protect against liver-stage malaria†

Meijlink MA, Chua YC, Chan STS, Anderson RJ, Rosenberg MW, Cozijnsen A, Mollard V, McFadden GI, Draper SL, Holz LE

RSC Chemical Biology (2022)

Characterisation of de-structured starch and its shear-thickening mechanism

Cai Ling, A., M.-M. Lara, M. S. Ian, S. Liam, J. B. E. Patrick, L. Kaiyang and G. Kelvin Kim Tha

Food Hydrocolloids (2022)

Emulsification properties of Puka Gum – An exudate of a native New Zealand tree (Meryta sinclairii): Effect of shear rate and Gum concentration

R. Latifa Maulida, M. S. Ian and M.-M. Lara

Food Hydrocolloids (2022)

Dynamics of pelagic mucilage produced by the invasive, cyclotelloid diatom, Lindavia intermedia, in oligotrophic lakes of New Zealand

M. Schallenberg, H. Borges, T. J. Bell, S. F. R. Hinkley and P. M. Novis

PLOS Water, Public Library of Science (2022)

2021

Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer

Luxenburger A, Bougen-Zhukov N, Fraser MG, Beetham H, Harris LD, Schmidt D, Cameron SA, Guilford PJ, Evans GB

Journal of Medicinal Chemistry (2021), pp. 18114-18142

Hydroarylation of olefins catalysed by a dimeric ytterbium(II) alkyl

Richardson GM, Douair I, Cameron SA, Bracegirdle J, Keyzers RA, Hill MS, Maron L, Anker MD

Nature Communications (2021)

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues

Paparella AS, Aboulache BL, Harijan RK, Potts KS, Tyler PC, Schramm VL

Nature Communications (2021)

Synthesis of N-acetylmannosamine-6-phosphate derivatives to investigate the mechanism of N-acetylmannosamine-6-phosphate 2-epimerase

Arif T, Currie MJ, Dobson RCJ, Newson HL, Poonthiyil V, Fairbanks AJ, North RA, Rendle PM

Carbohydrate Research (2021)

Selective Targeting of Splicing Factor Mutant Hematopoietic Stem and Progenitor Cells Via STAT3 Inhibition

Potts KS, Cameron RC, Ghazale N, Gupta V, Barajas JM, Wallace L, Leal-Cervantes A, Aluri S, Pradhan K, McKinstry M

Blood (2021), pp. 1509-1509

Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2 R,3 S)-2-Hydroxy-3-(nitromethyl)succinic acid

Mellott DM, Torres D, Krieger IV, Cameron SA, Moghadamchargari Z, Laganowsky A, Sacchettini JC, Meek TD, Harris LD

Journal of the American Chemical Society (2021), pp. 17666-17676

Mucosal-Associated Invariant T (MAIT) Cell Dysfunction and PD-1 Expression in Prostate Cancer: Implications for Immunotherapy

Jarvis EM, Collings S, Authier-Hall A, Dasyam N, Luey B, Nacey J, Painter GF, Delahunt B, Hermans IF, Weinkove R

Frontiers in Immunology (2021)

The Different Facets of Metal-Catalyzed C−H Functionalization Involving Quinone Compounds

Wood JM, de Carvalho RL, da Silva Júnior EN

The Chemical Record (2021), pp. 2604-2637

Inhibition of sars-cov-2 polymerase by nucleotide analogs from a single-molecule perspective

Seifert M, Bera SC, Van Nies P, Kirchdoerfer RN, Shannon A, Le TTN, Meng X, Xia H, Wood JM, Harris LD

eLife (2021)

In vitro effects of bis(N-[4-(hydroxyphenyl)methyl]-2-pyridinemethamine)zinc perchlorate monohydrate 4 on the physiology and interaction process of Leishmania amazonensis

Sangenito LS, Rodrigues HD, Santiago SO, Bombaça ACS, Menna-Barreto RFS, Reddy A, Branquinha MH, Velasco-Torrijos T, Santos ALS

Parasitology International (2021)

Chitin deacetylases are required for Epichloe€ festucae endophytic cell wall remodeling during establishment of a mutualistic symbiotic interaction with Lolium perenne

Noorifar N, Savoian MS, Ram A, Lukito Y, Hassing B, Weikert TW, Moerschbacher BM, Scott B

Molecular Plant-Microbe Interactions (2021)

MR1-dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis

Naidoo K, Woods K, Pellefigues C, Cait A, O'Sullivan D, Gell K, Marshall AJ, Anderson RJ, Li Y, Schmidt A

Allergy (2021), pp. 3155-3170

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Total Synthesis and Bioactivity Studies of Fungal Metabolite (-)-TAN-2483B

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Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy

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Cryo-EM structures reveal intricate Fe-S cluster arrangement and charging in Rhodobacter capsulatus formate dehydrogenase

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Isolation and Synthesis of Glycophospholipids from the extremophile Chthonomonas calidirosea

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Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi

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Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis

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Dissolution of Cellulose: Are Ionic Liquids Innocent or Noninnocent Solvents?

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One-Pot, Tandem Wittig Hydrogenation: Formal C(sp3)–C(sp3) Bond Formation with Extensive Scope

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The Synthesis and Anti‐tumour Properties of Poly Ethoxy Ethyl Glycinamide (PEE‐G) Scaffolds with Multiple PD‐1 Peptides Attached

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Bidirectional Synthesis of the IJK Fragment of Ciguatoxin CTX3C by Sequential Double Ring-Closing Metathesis and Tsuji–Trost Allylation

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International Journal of Biological Macromolecules 2020 Vol. 150 Pages 839-848

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Polysaccharide Structures in the Outer Mucilage of Arabidopsis Seeds Visualized by AFM

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Development, synthesis and biological investigation of a novel class of potent PC-PLC inhibitors

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European Journal of Medicinal Chemistry 2020 Vol. 191 Pages 112162

Combined Infection Control and Enhanced Osteogenic Differentiation Capacity on Additive Manufactured Ti-6Al-4V are Mediated via Titania Nanotube Delivery of Novel Biofilm Inhibitors

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Advanced Materials Interfaces 2020 Vol. 7 Issue 7 Pages 1901963

Vaccines adjuvanted with an NKT cell agonist induce effective T-cell responses in models of CNS lymphoma

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Immunotherapy 2020 Vol. 12 Issue 6 Pages 395-406

Distinct Dysfunctional States of Circulating Innate-Like T Cells in Metabolic Disease

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Frontiers in Immunology 2020 Vol. 11

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Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases

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The Chemical Synthesis, Stability, and Activity of MAIT Cell Prodrug Agonists That Access MR1 in Recycling Endosomes

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Ortho -Substituted lipidated Brartemicin derivative shows promising Mincle-mediated adjuvant activity

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Reisolation and NMR characterization of the satratoxins G and H

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Rh-Catalyzed [2 + 2 + 2] Cycloadditions with Benzoquinones: De Novo Access to Naphthoquinones for Lignan and Type II Polyketide Synthesis

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Pharmaceutics 2020 Vol. 12 Issue 12

A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis

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Structure-Function Implications of the Ability of Monoclonal Antibodies Against α-Galactosylceramide-CD1d Complex to Recognize β-Mannosylceramide Presentation by CD1d

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Frontiers in Immunology 2019 Vol. 10

Investigating potential wound healing properties of polysaccharides extracted from Grewia mollis Juss. and Hoheria populnea A. Cunn. (Malvaceae)

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Bioactive Carbohydrates and Dietary Fibre 2019 Vol. 20 Pages 100201

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Hamigeran G Does Not Affect Golgi Structure or Function in HEK293 Cells

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STAT3 INHIBITION IS A SYNTHETIC LETHAL VULNERABILITY FOR SF3B1-MUTATED HEMATOPOIETIC STEM CELLS

Potts K, Cameron R, Gupta V, Shastri A, Choudhary G, McKinstry M, Bai X, Verma A, Obeng E, Bowman T

Experimental Hematology 2019 Vol. 76 Pages S82-S83

The splicing factor Sf3b1 regulates erythroid maturation and proliferation via TGFb signaling in zebrafish

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Pyrroloquinoline derivatives from a Tongan specimen of the marine sponge Strongylodesma tongaensis

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Tetrahedron Letters 2019 Vol. 60 Issue 28 Pages 1825-1829

Utilization of complex pectic polysaccharides from new zealand plants (tetragonia tetragonioides and corynocarpus laevigatus) by gut bacteroides species

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Hinge Twists and Population Shifts Deliver Regulated Catalysis for ATP-PRT in Histidine Biosynthesis

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Molecular and structural insights into skin collagen reveals several factors that influence its architecture

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Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against malaria

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Cover Feature: Synthesis of Bioactive Side‐Chain Analogues of TAN‐2483B (Chem. Asian J. 8/2019)

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Synthesis and Microtubule-Destabilizing Activity of N-Cyclopropyl-4-((3,4-dihydroquinolin-1(2H)-yl)sulfonyl)benzamide and its Analogs

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Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase

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Journal of Medicinal Chemistry 2019 Vol. 62 Issue 7 Pages 3286-3296

Complex epigenetic regulation of alkaloid biosynthesis and host interaction by heterochromatin protein I in a fungal endophyte-plant symbiosis

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Fungal Genetics and Biology 2019 Vol. 125 Pages 71-83

E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function

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Gastric Cancer 2019 Vol. 22 Issue 2 Pages 273-286

The effects of trehalose glycolipid presentation on cytokine production by GM-CSF macrophages

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Biofilm Inhibition via Delivery of Novel Methylthioadenosine Nucleosidase Inhibitors from PVA-Tyramine Hydrogels while Supporting Mesenchymal Stromal Cell Viability

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2-Formylpyrrole natural products: Origin, structural diversity, bioactivity and synthesis

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Synthesis of 13 C-labelled sulfated N-acetyl-d-lactosamines to aid in the diagnosis of mucopolysaccharidosis diseases

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Journal of Labelled Compounds and Radiopharmaceuticals 2019 Vol. 62 Issue 2 Pages 67-76

Nodulisporic acid e biosynthesis:: In vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold

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MedChemComm 2019 Vol. 10 Issue 7 Pages 1160-1164

Synthesis and Thermal Properties of Bio-Based Copolyesters from the Mixtures of 2,5- A nd 2,4-Furandicarboxylic Acid with Different Diols

Thiyagarajan S, Meijlink MA, Bourdet A, Vogelzang W, Knoop RJI, Esposito A, Dargent E, van Es DS, van Haveren J

ACS Sustainable Chemistry & Engineering 2019 Vol. 7 Issue 22 Pages 18505-18516

Two new 4-methylidene containing steroids, craterol A and B, from the New Zealand two sponge association between Stelletta crater and Desmacella dendyi

Taufa T, Northcote PT, Keyzers RA

Steroids 2019 Vol. 141 Pages 9-13

Influence of albumin in the microfluidic synthesis of PEG-PLGA nanoparticles

Poller B, Painter FG, Walker FG

Pharmaceutical Nanotechnology 2019 Vol. 7 Issue 6 Pages 460-468

Design, synthesis and biological evaluation of isoxazole-based CK1 inhibitors modified with chiral pyrrolidine scaffolds

Luxenburger A, Schmidt D, Ianes C, Pichlo C, Krüger M, von Drathen T, Brunstein E, Gainsford GJ, Baumann U, Knippschild U, Peifer C

Molecules 2019 Vol. 24 Issue 5 Pages 873

Aziridination and aza-Wharton Reactions of Levoglucosenone

Ledingham ET, Greatrex BW

Australian Journal of Chemistry 2019 Vol. 72 Issue 5 Pages 362-368

Therapeutic potential of neurotrophins for repair after brain injury: A helping hand from biomaterials

Houlton J, Abumaria N, Hinkley SFR, Clarkson AN

Frontiers in Neuroscience 2019 Vol. 13

Enhancing T cell responses and tumour immunity by vaccination with peptides conjugated to a weak NKT cell agonist

Compton BJ, Farrand KJ, Tang C-w, Osmond TL, Speir M, Authier-Hall A, Wang J, Ferguson PM, Chan STS, Anderson RJ, Cooney TR, Hayman CM, Williams GM, Brimble MA, Brooks CR, Yong L-K, Metelitsa LS, Zajonc DM, Godfrey DI, Gasser O, Weinkove R, Painter GF, Hermans IF

Organic & Biomolecular Chemistry 2019 Vol. 17 Issue 5 Pages 1225-1237