mRNA malaria vaccine

Learn more about how the mRNA and lipid nanoparticles team is developing an mRNA vaccine to overcome the limitations of traditional malaria vaccines.

mRNA-Malaria-vaccine

The problem

Despite decades of research, traditional malaria vaccines have limitations, including poor efficacy and interference from previous infection.

The solution

We developed an mRNA vaccine incorporating a potent vaccine adjuvant which enables the generation of liver-resident memory T cells to prevent malaria.

The impact

Our mRNA vaccine shows promise for effective protection against malaria, particularly in malaria-endemic regions, as it is not impaired by previous exposure to blood-stage infection, unlike traditional vaccines.


Research team

mRNA and lipid nanoparticles team

Design and synthesis of vaccine adjuvants and ionisable lipids used in vaccines.

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Latest publications 2023

2023

Ganley M, Holz LE, Minnell JJ, de Menezes MN, Burn OK, Poa KCY, Draper SL, English K, Chan STS, Anderson RJ, Compton BJ, Marshall AJ, Cozijnsen A, Chua YC, Ge Z, Farrand KJ, Mamum JC, Xu C, Cockburn IA, Yui K, Bertolino P, Gras S, Le Nours J, Rossjohn J, Fernandez-Ruiz D, McFadden GI, Ackerley DF, Painter GF, Hermans IF, Heath WR

Nat Immunol (2023)

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